84-1165-85　Cathepsin G (CTSG, CG) 50ug　C2097-51A

特徴

• Cathepsins are a group of intracellular proteolytic enzymes located within the lysosomes.
• On the basis of the specificity towards their substrates, the cathepsins have been assigned the names: Cathepsins A, B, C, D, E, G H and L.
• Cathepsin G is a serine protease, it consists of a single polypeptide with a MW of 30kD as determined by SDS-PAGE.
• Its substrates are collagen and proteoglycans.
• Cathepsins are localized primarily in lysosomes or endosomes, but translocated to the cytosol during apoptosis.
• The translocation allows these proteases to interact with caspases or other apoptosis signaling mechanisms.
• Studies show that cathepsins cleave certain caspases, and caspase inhibitors can inhibit cathepsin activity in vitro.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, 11c7entrifuge the original vial after thawing and prior to removing the cap.