The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases.
THAP11, also known as Ronin, is a 3644kD member of the Thanatos-associated protein family.
It is ubiquitously expressed and through its repression of cMyc transcription, blocks cell proliferation.
Human THAP11 is 314aa in length.
It contains a DNA binding THAP zinc-finger domain (aa5-81), an NLS (aa98-104 a polyGln region (aa104-146 an Ala-rich segment (aa 197-221 and a C-terminal coiled coil region (aa255-305 THAP11 is phosphorylated on Thr25.
Over aa226-314 human and mouse THAP11 are 100% identical in aa sequence.
Applications:Suitable for use in ELISA.
Other applications have not been tested.
Recommended Dilutions: Peptide ELISA Titer: 1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by peptide affinity chromatography.
Form：Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
Specificity：Recognizes THAP11. Species sequence homology: human, mouse, rat, canine, bovine.
Isotype：IgG
Calc Applications Abbrev：E
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to C-GSDHSYSLSSGTTEE, from the internal region of human THAP11 (NP_065190.2)
