84-1164-60　Ring Finger Protein 7 (RNF7, CKII beta-binding Protein 1, CKBBP1, Regulator of Cullins 2, ROC2, RING Box Protein 2, Rbx2, Sensitive to Apoptosis Gene, Sensitive to Apoptosis Gene Protein, SAG, Zinc RING Finger Protein SAG) 100ug　R2993-81K

特徴

• The protein encoded by this gene is a highly conserved ring finger protein.
• It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction.
• This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII).
• The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B).
• Alternatively spliced transcript variants encoding distinct isoforms have been reported.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications have not been tested.
• Recommended Dilutions: Peptide ELISA Titer: 1:8000Western Blot: 1-3ug/ml ~11kD band observed in Human Human Heart lysates (calculated MW of 12.7kD according to NP_055060.1)
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.