Receptor Associated Protein 80 (RAP80) is a 79.8kD nuclear acidic protein.
RAP80 acts as a transcriptional repressor, inhibiting the interaction of NR6A1 with the co-repressor NCOR1.
Studies have demonstrated that RAP80 is recruited by CCDC98 to BRCA1 allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation.
Along with CCDC98, RAP80 is required for DNA damage resistance, G2-M checkpoint control and DNA repair.
RAP80 is highly expressed by germ cells of the testis and is also expressed in the ovary, thymus and heart.
Research has shown the existence of at least four isoforms of RAP80.
Applications:Suitable for use in ELISA.
Other applications have not been tested.
Recommended Dilutions: Peptide ELISA Titer: 1:32,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by peptide affinity chromatography.
Form：Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
Specificity：Recognizes RAP80. Species sequence homology: human, mouse, rat, canine, porcine.
Isotype：IgG
Calc Applications Abbrev：E
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to C-TRRQKEAKTKSDSG, from the internal region of human RAP80 (NP_057374.3).
