This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase.
This FAD-binding protein forms homodimers and reduces quinones to hydroquinones.
This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species.
Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer.
Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD).
Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Applications:Suitable for use in ELISA and Western Blot.
Other applications have not been tested.
Recommended Dilutions: Peptide ELISA Titer: 1:64,000Western Blot: 0.03-1ug/ml ~30kD band observed in Human Kidney and Lung lysates (calculated MW of 30.9kD according to NP_000894.1)
Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by peptide affinity chromatography.
Form：Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
Specificity：Recognizes human NQO1.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to C-SIPTDNQIKARK, from the C-terminus of human NQO1 (NP_000894.1; NP_001020604.1; NP_001020605.1). Species sequence homology: mouse, rat, canine, porcine.
