This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss.
Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse.
It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear.
Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Applications:Suitable for use in ELISA and Western Blot.
Other applications have not been tested.
Recommended Dilutions: Peptide ELISA Titer: 1:32,000Western Blot: 0.3-1ug/ml ~140kD band observed in lysates of cell line NIH3T3 (calculated MW of 141kD according to Human NP_005210.3 and 139kD according to Mouse NP_031884.1).
Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by peptide affinity chromatography.
Form：Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Specificity：Recognizes Diaphanous 1. Species crossreactivity: mouse. Species sequence homology: human. This antibody is expected to recognize both reported isoforms (NP_005210.3; NP_001073280.1).
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to C-QTKTSKAKKDQ, from the internal region of human Diaphanous 1 (NP_005210.3; NP_001073280.1).
