84-1162-86　RPA32 (Replication Protein A 32kD Subunit, Replication Factor A Protein 2, Replication Protein A2 (32kD), Replication Protein A2 32kDa, REPA2, RPA2, HSSB, p32, p34, RF-A Protein 2, RPA p32, RP-A p34, RPA34) 100ug　R3400-02M

特徴

• The p32 protein is a doughnut-shaped trimer that is primarily localized in the mitochondria.
• It has also been reported to be present at the cell surface and in the nucleus.
• The role of p32 in mammalian cells is unclear.
• The yeast p32 homologue has been reported to regulate oxidative phosphorylation, and a link to autophagy has been proposed.
• Elevated expression of p32 in cancer has also been noted.
• Additionally, p32 is primarily localized in hypoxic/nutrient-deprived regions within tumors and that, in addition to tumor cells, a tumor-associated macrophage/myeloid cell subpopulation closely linked to tumor lymphatics expresses high levels of p32.
• The expression of p32 at the cell surface, where it can be targeted with p32-binding antibodies and peptides, adds a second level of tumor specificity to p32 expression.
• The unique expression pattern of p32 in tumor cells, tumor lymphatics, and tumor-associated macrophages/myeloid cells makes p32 a potential target for the diagnosis and therapy of cancer.
• Applications: Suitable for use in Western Blot and Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 5ug/mlImmunocytochemistry: 1:500Optimal dilutions to be determined by the researcher.
• Positive Control:A431 cell lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.