Neurogenins are a family of bHLH transcription factors involved in specifying neuronal differentiation.
They are related to Drosophila atonal.
The neurogenins (ngns) make up one of these atonal-related gene families.
In neural crest cells, the atonal-related neurogenin family is particularly important for the sensory lineage (neurogenins are essential for the formation of dorsal root ganglia), while the achaete-scute homolog ash1 (Mash1) is important for aspects of autonomic neurogenesis (Mash1 is essential for noradrenergic differentiation).
Neurogenin 3 also promotes pancreatic development.
Applications: Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilutions:Western Blot: 1:1000 detected Neurogenin 3 on 10ug of mNgn3 transfected rabbit reticulocyte lysates
Immunohistochemistry: 1:500 detected Neurogenin 3 in mouse embryo E12.5+ tissue
Optimal dilutions to be determined by the researcher.
Positive Control:mNgn3 transfected and wildtype rabbit reticulocyte lysates
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：mouse
Grade：Serum
Purity：Serum
Form：Supplied as a liquid, 0.05% sodium azide.
Specificity：Recognizes mouse Neurogenin 3 at ~32kD.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Mo
Immunogen：Recombinant protein corresponding to the N-terminus of mouse Neurogenin 3, GST-tagged.
