84-1162-50　［取扱停止］Neuromedin U-8 (NmU-8, NMU) 50ul　N2171-80T

特徴

• Neuromedin U (or NmU) is a neuropeptide found in the brain of humans and other mammals, which has a number of diverse functions including contraction of smooth muscle, regulation of blood pressure, pain perception, appetite, bone growth, and hormone release.
• It was first isolated from the spinal cord in 1985, and named after its ability to cause smooth muscle contraction in the uterus.
• Neuromedin U is a highly conserved neuropetide present in many species, existing as multiple isoforms.
• For example, in humans it is a 25 amino acid peptide (U-25) in rats it is 23aa long (U-23) and it has been found to be as low as 8aa long in some mammals.
• NMU-8 is identical to the C-terminus of NMU-25, thus is the most highly conserved region of the entire peptide.
• The relative contribution of the different isoforms to the biological function of neuromedin U is generally not well understood.
• Neuromedin U, like many neuroactive peptides, is amidated at the C-terminus, and all isoforms have identical C-terminal heptapeptides.
• Applications:Suitable for use in Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry (Frozen): 1:1000-1:1500 using FITC.
• Incubate overnight at 4ºC
• Optimal dilutions to be determined by the researcher.
• Positive Control:Frozen sections of chicken small intestine.
• Storage and Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.