Parkin is thought to play a role in the ubiquitin/proteasome pathway for protein degradation.
The amino terminus bears sequence homology to ubiquitin while functionally it acts as a RING-type ubiquitin protein ligase (E3) that coordinates the transfer of ubiquitin to substrate proteins, thus targeting them for degradation by the proteasome.
Mutations in the human version of the protein are known to cause autosomal recessive juvenile parkinsonism.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:1,000 Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ul
Host：rabbit
Source Antibody：drosophila
Grade：Purified
Purity：Purified by ammonium sulfate precipitation.
Form：Supplied as a liquid in PBS, 0.09% sodium azide.
Specificity：Recognizes drosophila Parkin.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Dr
Immunogen：Synthetic peptide selected from the N-terminal region of Drosophila Parkin (KLH).
