84-1150-27　FGFR2 (Fibroblast Growth Factor Receptor 2, FGFR-2, Keratinocyte Growth Factor Receptor, K-sam, CD332, BEK, KGFR, KSAM) 200ul　F4305-16H

特徴

• FGFR2 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution.
• FGFR family members differ from one another in their ligand affinities and tissue distribution.
• A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain.
• The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.
• This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform.
• Mutations in FGFR2 gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis.
• Applications:Suitable for use in ELISA, Immunohistochemistry, Immunofluorescence, Indirect Flow Cytometry and Western Blot.
• Other applications not tested.
• Recommended Dilutions:Immunohistochemistry (FFPE): 1:10-1:50Immunofluorescence: 1:10-1:50Indirect Flow Cytometry: 1:10-1:50Western Blot: 1:1000Optimal dilutions to be determined by the researcher.
• Positive Control:NCI-H460 cell lysates, 293 cell lysates and U251 cells
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.