Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells.
A number of granzymes (A to G) have been isolated and cloned from mouse CTLs and NK cells, however in man, fewer have been cloned and identified.
One of these, human granzyme B, is involved in target cell apoptosis during lymphocyte-mediated cytotoxicity.
Exocytosis of granzyme-containing granules in the cytoplasm of the target cell leads to the induction of DNA fragmentation and apoptosis.
Applications:Suitable for use in ELISA Other applications have not been tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：1ml
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in 10mM PBS, pH 7.4.
Specificity：Recognizes Human Granzyme B.
Isotype：IgG
Calc Applications Abbrev：E
Calc Crossreactivity：Hu
Immunogen：A synthetic peptide from the middle of mature granzyme B of human origin. Cellular Localization: Granular cytoplasmic. Epitope: aa139-157 MW of Antigen: 32kD.
