84-1143-34　PRL3 (PTP4A3, PRL-3, PRL-R, Protein Tyrosine Phosphatase Type IVA, Member 3, Protein-tyrosine Phosphatase 4a3, Protein-tyrosine Phosphatase Of Regenerating Liver 3) 200ul　P9109-48C3

特徴

• The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs).
• PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes.
• This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif.
• Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane.
• Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth.
• Two alternatively spliced variants exist.
• PRL-3 expression was found to be up-regulated in human liver carcinoma compared with normal liver.
• Its expression in colorectal cancers may contribute to the establishment of liver metastasis.
• In a different study, PRL-3 is found to be expressed in tumor metastasis and vasculature, regardless of the tumor source.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.