84-1137-69　SQSTM1, CT (p62) Sequestosome-1, Phosphotyrosine-independent Ligand for the Lck SH2 Domain of 62kD, Ubiquitin-binding Protein p62, EBI3-associated Protein of 60kD, p60, EBIAP, ORCA, OSIL) 200ul　S0961-50A

特徴

• SQSTM1/p62 is an adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1.
• This protein may play a role in titin/TTN downstream signaling in muscle cells, and may also regulate signaling cascades through ubiquitination.
• This protein is involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.
• SQSTM1/p62 also appears to play a role in macroautophagic removal of intracellular protein aggregates.
• Cellular depletion studies of SQSTM1/p62 have indicated a role for association with LC3 and aggregate proteins in order to facilitate normal formation of the autophagosome.
• Applications:Suitable for use in ELISA, Western Blot, Immunofluorescence, and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:2000Immunohistochemistry (FFPE): 1:50-1:100Immunofluorescence: 1:50-1:100Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.