PP-2 C alpha/beta is heterodimer located in the mitochondrial matrix.
Within the pyruvate dehydrogenase complex, PP-2 C alpha/beta serves to catalyze the dephosphorylation and concomitant reactivation of the E1 component’s alpha subunit.
Mutations occurring in the PDP1 gene are the cause of a disease known as pyruvate dehydrogenase deficiency (PDP deficiency), which leads to neurological dysfunction from lactic acidosis.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500 detected PP-2 C alpha/beta on 10ug of L6 lysates
Optimal dilutions to be determined by the researcher.
Positive Control:L6 Cell Lysate.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Purified
Purity：Purified by ammonium sulfate precipitation.
Form：Supplied as a liquid in PBS, 0.08% sodium azide.
Specificity：Recognizes the alpha/beta regulatory subunit isotype of human phosphatase 2C (PP2C). PP 2C alpha/beta polyclonal antibody binds a 44-46kD protein. Species crossreactivity: rat.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Rt
Immunogen：Synthetic peptide corresponding to human Protein Phosphatase 2 C alpha/beta (KLH). Species Sequence homology: mouse and bovine.
