84-1129-55　Toso, CT (Regulator of Fas-induced Apoptosis, Fas Apoptotic Inhibitory Molecule 3, FAIM3) 100ug　T8067-50C

特徴

• Toso, also known as Fas Apoptotic Inhibitory Molecule 3 (FAIM3).
• Toso is expressed by lymphoid and hematopoietic cells and is up-regulated by T-cell activation.
• Toso expressing cells have increased resistance to Fas-, FADD-, and TNFalpha-induced apoptosis.
• Toso is membrane bound, and is thought to directly bind to FADD, disrupting DISC formation and thus inhibiting caspase-8 activation.
• Toso is a potential proto-oncogene, and could be a therapeutic target for use in the treatment of autoimmune diseases.
• Despite its predicted molecular weight, Toso often migrates at 60kD in SDS PAGE.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1-2ug/ml detects a band of ~43kD in human lung tissue lysate
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.