Retinoic acid receptor beta (RAR beta) is a 55kD transcriptional factor which is activated by retinoic acid.
Once activated RAR beta heterodimerizes with retinoid X receptors (RXRs) and translocates to the nucleus, where it stimulates the transcription of growth-inhibitory, differentiation-inducing genes.
In this way RAR beta mediates cellular signalling in embryonic morphogenesis and organogenesis.
The RAR beta exists as three isoforms, which are localised to the cytoplasm or subnuclear compartments.
Down-regulation of the RAR-b2 isoform occurs early in tumorigenesis, and is a tumor suppressor gene.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (paraffin): 5-15ug/mlRequires antigen retrieval using heat treatment for 20 minutes prior to staining of paraffin sections.
0.01 M sodium citrate buffer, pH 6.0 is recommended
Optimal dilutions to be determined by the researcher.
Positive Control:Intermediate trophoblasts
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH7.7, 0.09%sodium azide.
Specificity：Recognizes an epitope within the C-terminal of human retinoic acid receptor beta. Does not crosreact with rat.
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to the C-terminal region of human RAR beta.
