Protein kinase C zeta (PKCz) is a 70kD member of the PKC family of serine/threonine kinases.
PKCz is a member of the atypical PKC subfamily and has been widely implicated in the regulation of many cellular functions.
PKCz activation is involved in the mitogen-activated protein kinase cascade, transcriptional factor NFkB activation, ribosomal S6-protein kinase signalling, and cell polarity.
PKC zeta may be a potential therapeutic target in asthma, and may have a putative role in other pulmonary diseases, including chronic obstructive pulmonary disease (COPD) and lung cancer
Applications:Suitable for use in Immunohistochemistry (paraffin).
Other applications not tested.
Recommended Dilution:Immunohistochemistry (paraffin): 2-10ug/mlRequires antigen retrieval using heat treatment for 20 minutes prior to staining of paraffin sections.
Optimal dilutions to be determined by the researcher.
Positive Control: Brain, cerebellum
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes an epitope within the N-terminal region of human protein kinase C zeta.
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide correspong to a region near the N-terminus of human protein kinase C zeta.
