TACR3 otherwise known as NK3 Receptor (NK3R), is a 52.2kD multi-pass membrane protein belonging to the G-protein coupled receptor 1 family.
TACR3 is a receptor for the tachykinin neuropeptide, neuromedin-k otherwise known as neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei.
Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system, and it is likely that these signals lead to the release of vasopressin and oxytocin into the circulation.
Studies with mice indicate that TACR3 is involved in learning and memory.
Applications:Suitable for use in Immunohistochemistry (paraffin) and Western Blot.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (paraffin): 5ug/mlWestern Blot: 0.5-1ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes human TACR3. Does not recognize NK1R or NK2R. Species Crossreactivity: mouse.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo
Immunogen：A 18aa peptide from near the centre of human TACR3.
