NALP3 is a cytoplasmic protein belonging to the NLRP family.
NALP3 is involved in inflammation and immune response.
Research indicates that NALP3 may function as an activator of NF-kappaB signalling and play a role in the regulation of inflammation and apoptosis.
Mutations in the NALP3 gene have been associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID).
NALP3 is strongly expressed in polymorphonuclear cells, osteoblasts and chondrocytes, NALP3 can also be detected in non-keratinizing epithelia of oropharynx, esophagus and ectocervix and in the urothelial layer of the bladder.
Applications:Suitable for use in ELISA and Immunohistochemistry (paraffin).
Other applications not tested.
Recommended Dilution:Immunohistochemistry (paraffin): 2.5ug/mlELISA: 1:23,000Requires antigen retrieval using heat treatment prior to staining of paraffin sections
Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in TBS, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Specificity：Recognizes human NACHT, LRR and PYD domains-containing protein 3 (NALP3). Species crossreactivity: rat.
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu Rt
Immunogen：Synthetic peptide sequence corresponding to C-EKPELTVVFEPSW from the C-terminus of human NALP3 (NP_004886).
