84-1127-76　［取扱停止］Inhibin, alpha (INHa) 1ml　I7652-90

特徴

• The inhibin alpha chain is a 366 amino acid polypeptide with a predicted molecular weight of ~40kD.
• It is composed of an N-terminal 18 amino acid signal peptide, two pro-peptide regions of 43 and 171 amino acids respectively and the 134 amino acid inhibin alpha chain.
• Inhibin alpha dimerizes with with inhibin beta A to form Inhibin A or with the inhibin beta B chain to form inhibin B.
• The active inhibin alpha chain is derived by cleavage of the inhibin alpha chain from the pro-peptide domains and subsequent dimerization through appropriate disulphide bond formation.
• Inhibins regulate follicle stimulating hormone secretion from the pituitary gland (Lumpkin et al.
• 1981).
• Inhibin alpha is expressed in the testis (Bergh and Cajander 1990) and ovary (Cuevas et al.
• 1987, Yamoto et al.
• 1992).
• Inhibin alpha expression has also been noted in the adrenal glands (McCluggage et al.
• 1998), endomertium (Mylonas et al.
• 2004) and brain (Uccella et al.
• 2000).
• Inhibin alpha expression has also been noted in a variety of neooplastic tissues including Leydig cell tumors (de Winter et al.
• 1992), brain tumors (Demura et al.
• 1995), ovarian cancers (Cooke et al.
• 1995) and adrenal carcinomas (Pelkey et al.
• 1998).
• Applications:Suitable for use in ELISA and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry (paraffin): 1:100-1:500Optimal dilutions to be determined by the researcher.
• Recommended Immunohistochemistry Positive Control Tissue:Human ovarian cortex
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.