Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases.
Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis.
Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 (for DAP kinase-related apoptosis-inducing protein kinases.
DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain.
Overexpression of DRAK2 induces apoptosis.
DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities.
DRAK2 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:32000Western Blot: 1-3ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris saline, pH7.3, 0.5% BSA, 0.02% sodium azide.
Specificity：Recognizes human DRAK2. Sequence Homology: canine.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to C-HSVRSSEDKTSK, from the internal region of thuman DRAK2 (NP_004217.1).
