84-1127-06　PAR1 (Proteinase Activated Receptor 1, F2R) 100ug　P3105-60H

特徴

• Human Proteinase-Activated Receptor 1 (hPAR1), also known as thrombin receptor, is a 45kD, 399 amino acid long member of the seven-transmembrane superfamily of cell-surface G protein-coupled receptors.
• PAR1 is activated by thrombin cleavage of its N-terminal propeptide in the extracellular domain.
• Human PAR1 is widely expressed in many cell types including endothelial cells, and it has been implicated in a variety of inflammatory responses.
• Over the regions used as immunogen, human and mouse PAR1 proteins are 58% identical in the region spanning the propeptide and extracellular domains, and 84% identical in the cytoplasmic tail.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilutions:ELISA (Peptide): 1:32,000Western Blot: 0.5-2ug/ml.
• A band at ~48kD was detected in HeLa lysates
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.