Several subtypes of NPY Receptors have been described of which the cloned Y1-, Y2- and Y5-receptors, members of the superfamily of G-protein coupled receptors, appear to be the endogenous binding sites for NPY.
The Y(2) receptor is the predominant Neuropeptide Y (NPY) receptor subtype in the brain.
Y(2) receptor-mediated effects have been reported principally based on the observations using the C-terminal fragments of NPY.
Recent studies indicate an involvement of the receptor in food intake, gastrointestinal motility, cardiovascular regulation, and neuronal excitability.
NPY Y2 Receptor is a 7-transmembrane G-protein coupled receptor N-terminal peptide.
This sequence is the extracellular (ecto-domain) portion of the native receptor.
Useful in functional studies because the cells do not need to be permeablized for the antibody to bind.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 1:32,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
Specificity：Recognizes mouse NPY2R. Species crossreactivity: rat. Sequence homology: human, dog.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Mo Rt
Immunogen：Synthetic peptide corresponding to C-KAKKNLEVKKNN from the internal region of mouse NPY2R (NP_032757.1).
