84-1126-58　APOB48R (Apob48r, Apolipoprotein B48 Receptor, Apob-48) 100ug　A2299-55C

特徴

• Apo B exists in human plasma as two isoforms: apo B48 and apo B100.
• Apo B100 is the major physiological ligand for the LDL receptor.
• It contains 4536 amino acid residues.
• Apo B100 is the full length protein.
• Its gene has been mapped on the short arm of chromosome 2, with an approximate length of 43 kilobases and 29 exons.
• The LDL-binding domain of the molecule is proposed to be located between the aa3129-3532.
• Apo B100 is synthesized in the liver.
• It is required for the assembly of very low density lipoproteins (VLDL).
• It does not interchange between lipoprotein particles, as do the other lipoproteins.
• It is found in IDL and LDL particles after the removal of the apolipoproteins A, E and C.
• Apo B48 is present in chylomicrons and chylomicron remnants.
• It plays an essential role in the intestinal absorption of dietary fats.
• Apo B48 is synthesized in the small intestine.
• It comprises the N-terminal 48% of apo B100.
• Apo B48 is the degraded protein.
• Apo B48 lacks the LDL receptor-binding domain of Apo B100.
• It is produced due to post-transscriptional Apo B100 mRNA editing at codon 2153, which creates a stop codon in the intestine instead of a glutamine in the liver.
• Applications:Suitable for use in ELISA.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:32,000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.