84-1126-44　Regenerating Protein 1 alpha (REG-1 alpha) 100ug　R1455-01

特徴

• Reg protein was shown to be stimulated during the regeneration of pancreatic islets.
• Since then, many Reg-related proteins have been identified in humans and other animals.
• In human, the four REG family genes, i.e., REG 1 alpha, REG 1 beta, REG-related sequence (RS) and HIP/PAP, have so far been isolated.
• These Reg-related proteins are classified into four subfamilies according to their aa sequences, but they share a similar structure and physiological function.
• Reg is a growth factor for pancreatic beta cells and suggests that the administration of Reg could be used as another therapeutic approach for diabetes mellitus.
• Human REG cDNA encodes a 166aa protein with a 22aa signal peptide.
• The aa sequence of human REG has 68% homology to that of rat Reg.
• Reg 1 was found to be expressed mainly in pancreatic beta and acinoductular cells as well as gastric fundic enterochromaffin-like (ECL) cells.
• Reg I production in ECL cells is stimulated by gastrin, as well as by the proinflammatory cytokine, cytokine-induced neutrophil chemoattractant (CINC)-2Beta.
• In patients with chronic hypergastrinemia, Reg production is stimulated with the increased proliferation of gastric mucosal cells.
• Patients with Helicobacter pylori infection also showed increased Reg production in the gastric mucosa, partly via increased plasma gastrin concentration and partly via increased proinflammatory cytokine production.
• The serum concentration of the reg-protein was significantly higher in patients with various pancreatic diseases than in normal controls, and was also significantly higher in patients with acute pancreatitis or chronic relapsing pancreatitis than in patients with chronic pancreatitis.
• Furthermore, the serum PSP/reg-protein concentration was also significantly increased in liver cirrhosis, choledocholit-hiasis and various cancers of the digestive system.
• Applications:Suitable for use in ELISA, Western Blot, Immunoprecipitation and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stabillty:Lyophilized powder may be stored at -20°C.
• Stable for 12 months at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.