Fetuin-A (AHSG),59kD glycoprotein, consisting of two cystatin-like domains and a smaller unrelated domain, is predominantly sinthetized in liver .
It is secreted into the blood stream and deposited as a noncollagenous protein in mineralized bones and teeth.
Fetuin-A occurs in high serum concentrations during foetal life, whereas its level declines following infection, inflamatory and malignancy.
Fetuin-A acts as an important circulating inhibitor of ectopic calcification, frequent complication of many degenerative diseases.
Low serum level of Fetuin-A is associated with vascular and valvular calcification, atherosclerosis, malnutrition and higher cardiovascular mortality in chronic renal failure, liver cancer and liver cirrhosis patients on long-term dialysis.
AHSG protein represents a natural inhibitor of tyrosinase kinase activity of the insulin receptor.
It may play a significant role in regulating postprandial glucose disposal, insulin sensitivity, weight gain, and fat accumulation.
The serum and bone-resident Fetuin-A binds to transforming growth factor- beta and blocks TGF- beta binding to cell surface receptors.
Applications:Suitable for use in ELISA, Immunoturbidimetry and Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stabillty:Lyophilized powder may be stored at -20°C.
Stable for 12 months at -20°C.
Reconstitute with sterile ddH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Immunoaffinity chromatography.
Form：Supplied as a lyophilized powder in PBS, pH 7.2. No preservative added. Reconstitute with 100ul sterile dH2O. Let the lyophilized pellet dissolve completely.
