It has been suggested that the hormone resistin secreted by adipocytes, links obesity to type 2 diabetes by modulating steps in the insulin-signaling pathway and inducing insulin resistance.
Levels of circulating resistin decrease following treatment with the anti diabetic drug rosiglitazone and increase in diet-induced and genetic forms of obesity.
In addition, treatment of normal mice with recombinant resistin impairs glucose tolerance and insulin action.
Insulin-stimulated glucose uptake by adipocytes is enhanced by neutralization of resistin and is reduced by resistin treatment.
Applications:Suitable for use in ELISA.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C.
Reconstitute with sterile ddH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：20ul
Host：rabbit
Source Antibody：human
Grade：Serum
Purity：Serum
Form：Supplied as a lyophilized powder in 50mM Tris, pH 7.2. Reconstitute in ddH2O.
Specificity：Recognizes human Resistin (aa 33-90)
Isotype：IgG
Calc Applications Abbrev：E
Calc Crossreactivity：Hu
Immunogen：Synthetic human Resistin (aa 33-90) bTG-conjugated(CQSVTSRGDLATCPRGFAVTGCTCGSACGSWDVRAETTCHCQCAGMDWTGARCCRVQP)
