84-1124-21　Plasminogen Activator Inhibitor Type 1 (PAI-1, Clade E, Endothelial plasminogen activator inhibitor, Nexin, PLANH1, Serine (or cysteine) proteinase inhibitor, Serpin peptidase inhibitor clade E, Serpine1) 100ul　P4256-32L

特徴

• Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angiogenesis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation.
• The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer.
• PAI-1 is activated by the glycoprotein vitronectin.
• Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration.
• This binding has proven to be an important inhibitor of the activated form of protein C (APC).
• Applications:Suitable for use in ELISA, RIA and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry (frozen): 1:50-1:100Immunohistochemistry (paraffin): 1:50.
• Recommend pretreatment with 0.05% Pronase E for 20 minutes
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.