84-1120-86　［取扱停止］Delta 4 (Delta-like Protein 4, DLL4, DLL-4, Delta Ligand 4 Precursor, Drosophila Delta Homolog 4, hdelta2, MGC126344, Notch Ligand DLL4 Precursor) 50ug　D2728-01D

特徴

• DLL4 is expressed in the vasculature and plays a critical role in vascular development.
• It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formation of a differentiated vascular network.
• DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation.
• This in turn leads to a decrease in tumor growth, with no apparent toxicity.
• Applications:Suitable for use in ELISA, Immunohistochemistry and Western Blot.
• Other applications not tested.
• Recommended Dilutions:Immunohistochemistry (Paraffin): 5-15ug/mlELISA: 1:3000-1:15000Western Blot: 1:300-1:1500.
• Detects a band at ~74kD in pancreatic cell lysates
• Optimal dilutions to be determined by the researcher.
• Positive Control: human ovary
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.