Carabin is a 50kD protein belonging to the TBC1 domain family of proteins.
Carabin differs from other members of the TBC1 domain protein family, which appear to play a role in the regulation of cell growth and differentiation.
Studies demonstrate that Carabin is part of a negative regulatory loop for the intracellular TCR signalling pathway and acts as an inhibitor of the Ras signalling pathway.
Carabin is also believed to mediate crosstalk between calcineurin and Ras.
Carabin is most abundantly expressed in spleen and peripheral blood leucocytes.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1-2ug/mlOptimal dilutions to be determined by the researcher.
Positive Control:Human spleen cell lysates
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes human Carabin at ~55kD. Does not crossreact with either TBC1D10A or TBC1D10B. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to a 17aa from near the amino terminus of human Carabin.
