84-1118-74　NT-4 Propeptide (Neurotrophin 4, Neurotrophin-4, NT4, Neutrophic Factor 4, NTF4, Neurotrophin 4/5, NT-4/5, NTF4/5, Neurotrophin 5, Neurotrophin-5, NT5, NT-5, Neutrophic Factor 5, NTF5) 100ug　N6000-12C

特徴

• NT-4 Propeptide (neurotrophin-4/5) is a 27kD, secreted, glycosylated neuronal polypeptide that belongs to the NGF-b family of neurotrophic factors.
• It is synthesized as a proform that contains a 9kD, 56aa proregion (aa25-80) and a 130aa mature segment.
• The mature molecule forms both nondisulfide linked heterodimers (with NGF) and homodimers.
• It is unclear if 186aa NT-4 Propeptide dimerizes, but this might be anticipated.
• Proneurotrophins are believed to activate NGFR and sortilin complexes and neurotrophin proregions regulate neurotrophin maturation.
• Over aa25-80, human NT-4 Propeptide is 89% and 91% aa identical to mouse and canine NT-4 Propeptide, respectively.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:ELISA: 0.5-1ug/mlWestern Blot: 1ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C for short-term only.
• Reconstitute with sterile 40-50% glycerol, aliquot and store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.