Mutations in spectrins are a previously unknown cause of ataxia and neurodegenerative disease that affect membrane proteins involved in glutamate signaling.
Spectrin-beta IIs have been recognized as ataxia disease genes and their mutations cause spinocerebellar ataxia type 5 (SCA5).
Applications:Suitable for use in Immunohistochemistry and Immunoprecipitation.
Other applications not tested.
Recommended Dilution:Immunohistochemistry: 2.5-5ug/ml Immunoprecipitation: 2-5ug/mg lysateOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C.
Aliquots are stable for at least 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid.
Specificity：Recognizes human Spectrin, beta 2. Species Sequence Homology: Mouse and rat - 100%.
Isotype：IgG
Calc Applications Abbrev：IHC IP
Calc Crossreactivity：Hu
Immunogen：The epitope recognized by this antibody maps to a region between residues 2150 and 2200 of human spectrin, beta, non-erythrocytic 2 (spinocerebellar ataxia 5) using the numbering given in entry NP_008877.1
