84-1116-43　Serine/threonine kinase 11-interacting protein (LKB1-interacting protein 1, STK11IP, KIAA1898, LIP1, LKB1IP, STK11IP1) 100ug　S7973-58W

特徴

• LKB1 (also STK11 and JBS) is a 55kD member of the CAMK Ser/Thr protein kinase family.
• It is ubiquitously expressed, and considered to be a tumor suppressor.
• LKB1 is both nuclear and cytoplasmic, and appears to contribute to cell polarization, G1 cell cycle arrest and Wnt signaling.
• It is known to complex with STRAD and CAB39/MO25, and phosphorylate PTEN plus p53.
• Human LKB1 is 433 amino acids (aa) in length.
• It contains a protein kinase domain (aa 49-309) and a prenylation motif (CysLysGlnGln) over aa 430-433.
• There are two potential isoforms of LKB1.
• One shows a nine aa insertion after Tyr126, while another shows a 34 aa substitution for aa 371-433.
• Over aa 242-433, human and mouse LKB1 are identical in aa sequence.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:164000Western Blot: 0.3-1ug/mlOptimal dilutions to be determined by the researcher.
• Positive Control:Human Ovary lysates
• Storage and Stability:May be stored at 4°C for short-term only.
• For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C.
• Aliquots are stable for at least 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.