CD184, otherwise known as CXCR4 (C-X-C chemokine receptor type 4), is a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, ubiquitously expressed in blood and tissue cells, which acts as a specific receptor for the chemokine SDF-1 (Stromal cell-derived factor 1).
Interaction of CD184 with SDF-1 mediates the chemotaxis of progenitor and mature blood cells, and is critical for B-lymphopoiesis and myelopoiesis.
CD184 is a major co-receptor for infection by T-cell tropic strains of HIV1, and also a primary receptor for some HIV2 isolates.
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilutions:ELISA (Indirect): 1:50,000Wester Blot: 1:1000Immunohistochemistry (Paraffin): 1:300Optimal dilutions to be determined by the researcher.
Positive Control:Spleen
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by affinity chromatography
Form：Supplied as a liquid in PBS, pH 7.2, 0.1% BSA, 0.09% sodium azide
Specificity：Recognizes an epitope within the N-terminal region of mouse CD184. Species Crossreactivity: Xenopus
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Mo Xe
Immunogen：Synthetic peptide corresponding to aa14-40, YSEEVGSGDYDSNKEPCFRDENVHFNR within the N-terminal region of mouse CD184.
