CCR6 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein coupled receptors.
It is preferentially expressed by immature dendritic cells and memory T cells.
The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP 3 alpha).
This receptor has been shown to be important for B lineage maturation and antigen driven B cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses.
CCR6 has been reported to be expressed in intestine, colon, liver, lymph node, spleen, lung, blood, umbilical cord, placenta, skin, and pancreas.
It has also been reported to be expressed in lymphocytes, T cells, and B cells.
Applications:Suitable for use in Indirect ELISA, Immunohistochemistry and Western Blot.
Other applications not tested.
Recommended Dilutions:ELISA: 1:35,000Immunohistochemistry (Paraffin): 1:125Western Blot: 1:250Optimal dilutions to be determined by the researcher.
Positive Control: Human spleen or peripheral blood and mouse spleen
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.1% BSA, 0.09% sodium azide.
Specificity：Recognizes human CD196. Species Crossreactivity: mouse.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to aa18-46, YFVSVNTSYYSVDSEMLLCSLQEVRQFSR of human CCR6.
