CCR2 (C-C chemokine receptor type 2 is a transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, which acts as a receptor for the chemokines MCP-1 (monocyte chemoattractant protein 1), MCP-3 and MCP-4.
Interaction between CD192 and MCP-1 initiates chemotactic responses, through an increase in intracellular calcium levels.
CD192 acts as a co-receptor with CD4 for HIV1 infection, and variations in CD192 are associated with relative resistance to HIV1.
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:ELISA: 1:60,000Western Blotting: 1:1000Immunohistochemistry (paraffin): 1:200Optimal dilutions to be determined by the researcher.
Positive Control:Spleen
Storage and Stability:May be stored at 4°C for short-term only.
For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C.
Aliquots are stable for at least 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in 10mM KHPO4, 140mM sodium chloride, pH 7.2, 0.09% sodium azide, 0.1% BSA.
Specificity：Recognizes an epitope within the N-terminal region of human CCR2.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide CGEEVTTFFDYDYGAPCHKFDVKQ corresponding to aa17-39 within the N-terminal region of human CCR2.
