84-1115-62　HMG4 (High Mobility Group 4 (HMG) Transcription Factor, High Mobility Group Protein 2a, HMG2a, High Mobility Group Box 3, HMGB3, MGC90319, Nonhistone Chromosomal Protein HMG4) 100ug　H6202-40A

特徴

• Hmgb3 belongs to the high mobility group HMG) protein superfamily.
• It contains DNA-binding HMG box domains and is thought to play a fundamental role in DNA replication, nucleosome assembly and transcription.
• Hmgb3 is a sequence-independent chromatin-binding proteinthat is preferentially expressed in hematopoietic stem cells.
• It can alter DNA structure to facilitate transcription factor binding.
• Enforced expression of Hmgb3 inhibits B-cell andmyeloid differentiation and thus, down-regulation of Hmgb3 protein levels has been concluded to be an important step for myeloid and B-cell differentiation.
• Hmgb3 deficiencypossibly leads to a failure of hematopoietic stem cells to expand into normal numbers of common lymphoid progenitors and common myeloid progenitors.
• Hmgb3 progenitors attain the ability to expand rapidly and differentiate into normal numbers of hematopoietic cells.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:64000Western Blot: 0.01-0.03ug/mlOptimal dilutions to be determined by the researcher.
• Positive Control:Human Lung lysates
• Storage and Stability:May be stored at 4°C for short-term only.
• For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C.
• Aliquots are stable for at least 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.