84-1114-89　ABCA4 (ATP Binding Cassette Sub-family A Member 4, ATP-binding Cassette Sub-family A (ABC1) Member 4, ABCA 4, ABCR, ARMD 2, ARMD2, ATP Binding Cassette 10, ABC10, ATP-binding Transporter Retina Specific, CORD3, FFM, Photoreceptor Rim Protein, Retina-specific ABC Transporter, Retinal-specific ATP-binding Cassette Transporter, RIM ABC Transporter, RIM Protein, RmP, RP19, Stargardt Disease Protei ...　A0004-02D2

特徴

• The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.
• ABC proteins transport various molecules across extra- and intracellular membranes.
• ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
• This protein is a member of the ABC1 subfamily.
• Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes.
• This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate.
• It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane.
• Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration.
• Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2.
• Applications:Suitable for use in ELISA.
• Other Applications not tested.
• Recommended Dilutions:ELISA: 1:32,000Optimal dilutions to be determined by the researcher
• Control Peptide:A0004-02D2-P
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.