TREK-1 is a two-pore-domain background potassium channel expressed throughout the central nervous system.
It is opened by polyunsaturated fatty acids and lysophospholipids.
As well, it is regulated by various neurotransmitters.
It has been shown that alterations in the functioning, regulation, or both of the TREK-1 channel may alter mood.
TREK-1 is also activated by volatile anesthetics and has been suggested to be an important target in the action of these drugs.
Therefore, this particular K+ channel emerges as a potential innovative target for developing new therapeutic agents for anesthesiology and neurology, such as antidepressants.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilutions:ELISA: 1:500,00Western Blot: 1:3000Optimal dilutions to be determined by researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Stable for 12 months at -20°C.
Reconstitute by adding sterile 40-50% glycerol, ddH2O.
Aliquot and store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Purified
Purity：Purified
Form：Supplied as a lyophilized powder from 0.01M PBS, pH 7.4. Reconstitute with 100ul of sterile ddH2O.
Specificity：Recognizes human Twik-related potassium channel 1 protein, 47kD.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide (SASRERPGYTA) derived from the aa4-14 of TREK-1, (KLH).
