Fasciculation and elongation protein zeta-2 (FEZ2) is a homolog to the mammalian FEZ1, itself an ortholog of the C.
elegans UNC-76 (1,2).
In contrast to FEZ1, FEZ2 mRNA is widely expressed in mouse tissues.
FEZ2 interacts with protein kinase C (PKC)-ζ substrate and induces neurite extension of PC12 cells when co-expressed with a constitutively active form of PKC-ζ, suggesting FEZ2 may play an important role in the morphological changes of various cells by associating with PKC-ζ in a tissue non-specific manner (1).
FEZ2 can interact with FEZ1 through its c- terminal regions and especially its coiled-coil region (5).
At least two isoforms of FEZ2 are known to exist.
Applications:Suitable for use in Western Blot Other applications not tested.
Recommended Dilution:Western Blot: 0.5–1ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C.
Aliquots are stable for at least 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes human FEZ2. Species crossreactivity: Mouse and rat.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Ca Hu Mo Rt
Immunogen：Synthetic peptide corresponding to 15aa from near the carboxy terminus of human FEZ2 (Genbank accession No. NP_001036013).
