84-1113-56　［取扱停止］APBA1 (Amyloid beta (A4) precursor protein-binding, family A, member 1, Adapter protein X11alpha, amyloid beta (A4) precursor protein-binding, family A, member 1 (X11), Amyloid beta A4 precursor protein-binding family A member 1, D9S411E, MINT1, Mint-1, Neuronal Munc18-1-interacting protein 1, Neuron-specific X11 protein, X11, X11A, X11ALPHA) 100ug　A2275-71K

特徴

• Amyloid Precursor Protein (APP) is an integral membrane protein with a large ectodomain, a transmembrane domain, and a short cytoplasmic tail.
• APP is proteolytically cleaved by b-secretase (BACE) to generate the APP N-terminal fragment (sbAPP) with Mr 100kD and a C-terminal fragment (C99) with Mr 12kD.
• The smaller 12kD fragment can be further cleaved by g-secretase, an enzyme activity recently attributed to presenilin-2.
• This second cleavage produces the insoluble b-amyloid (Ab), a peptide of ~4kD.
• The accumulation of b-amyloid in intracellular neurofibrillary tangles and extracellular plaques is observed in the brains of Alzheimer’s disease patients and Downs’s Syndrome patients.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:16000Western Blot: 0.1-0.3ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C.
• Aliquots are stable for at least 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.