The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases.
The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5.
The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics.
Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis.
Multiple transcript variants encoding different isoforms have been found for this gene.
Applications:Suitable for use in ELISA.
Other applications not tested.
Recommended Dilution:ELISA: 1:8000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C.
Aliquots are stable for at least 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in 0.5 mg/ml tris-saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Specificity：Recognizes ALS2. Species Crossreactivity: Canine, mouse and rat.
