84-1111-96　GABA Receptor A, alpha 6 (Gamma-aminobutyric Acid Receptor Type A alpha 6 Subunit, GABRA6) [KO Validated] 100ul　G1015-21

特徴

• GABA A (gamma-aminobutyric acid-type A) receptors are members of the cysteine-loop family of neurotransmitter-gated ion channels.
• GABA binding to A-type receptors induces anion-selective ion channel opening.
• These receptors are the principal fast inhibitory neurotransmitter receptors in the CNS.
• GABA A receptors are heteropentamer combinations of seven subunit types; alpha, beta, gamma, delta, epsilon, theta, and pi.
• Three subunits, alpha, beta, and gamma, have at least three separate gene products in mammals, and typical GABA A receptors have some combination of alpha, beta and gamma subunits.
• The rat alpha 6 isoform is a 57kD, 434, 4 transmembrane protein with two terminal extracellular regions.
• The ligand-binding region is in the N-terminus (aa14-221).
• The expression of the subunit is strongly associated with cerebellar granule cells.
• The alpha 6 subunit has also been linked to alcohol sensitivity, possible due to a point mutation substitution of arginine for a glutamine at aa position 81 in the extracellular N-terminus.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.