84-1111-18　ADAM 19 (A Disintegrin And Metalloproteinase 19) (Biotin) 50ug　A0859-38

特徴

• ADAM19 (a disintegrin and metalloprotease 19; also MADDAM and Meltrin-beta) is a 95-100 kD member of the M12B peptidase family of enzymes.
• It is expressed on multiple cell types including monocytes, fibroblasts, osteoblasts and dendritic cells.
• The human ADAM19 proenzyme is a 931 amino acid (aa) type I transmembrane protein.
• It contains a 178aa cleavable proregion (aa26-203) and a 497 aa extracellular domain (ECD) (aa204-702).
• The ECD contains a metalloprotease domain (aa211-409), a disintegrin region (aa417-503) and a Cys-rich domain (aa504-650).
• The ECD circulates in plasma bound to 700 kD alpha 2-Macroglobulin.
• One splice variant shows an alternate start site at Met71, while two isoforms show variations afterLys902.
• Over aa205-702, human ADAM19 is 87% aa identical to mouse ADAM19.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.2ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at 4°C for short-term only.
• Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.