84-1110-82　TrkB (Tyrosine Kinase Receptor B) (BDNF, NT-3 growth factors receptor, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, GP145-TrkB/GP95-TrkB, Trk-B, Ntrk2, Trkb) 100ul　T8663-20K

特徴

• Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF).
• Involved in the development and/or maintenance of the nervous system.
• This is a tyrosine-protein kinase receptor.
• Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.
• Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
• Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (By similarity).
• Binds APS.
• Interacts with SQSTM1.
• Applications:Suitable for use in Immunohistochemistry.
• Other applications have not been tested.
• Recommended Dilutions:Immunohistochemistry: 1:1000-1:3000Optimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months at -20°C.
• Reconstitute with sterile 40-50% glycerol, ddH2O.
• Reconstituted product is stable for 12 months at -20°C.
• Aliquot and store at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.