84-1110-37　SURFACTANT PROTEIN C (SP-C, Pro, SFTPC, SFTP2) 100ug　S8403

特徴

• There are four surfactant-specific proteins, designated surfactant protein A (SP-A), SP-B, SP-C and SP-D respectively.
• SP-A and SP-D are hydrophilic surfactant proteins and are members of the collectin family.
• SP-B and SP-C are hydrophobic surfactant proteins and may be the most appropriate indicators for the evolutionary origin of surfactant.
• SP-C is a 34-35 amino acid peptide, of 4kD that is proteolytically processed from a 21kD precursor protein.
• SP-C is initiated early in the embryogenic period of lung formation, where SP-C transcripts are detected uniformly in epithelial cells lining the primitive airways.
• During lung development SP-C expression is decreased in cells of the proximal conducting portion of the lung.
• Ultimately SP-C is expressed selectively in type II epithelial cells in the alveolus of the lung.
• SP-C is secreted into the airspace where it enhances the spreading and stability of surfactant phospholipids in the alveolus.
• SP-C plays an important role in the spreading and stabilization of phospholipid films in the alveolus.
• SP-C is essential for air-breathing in mammals and is therefore largely conserved.
• Deficiency of SP-C and other surfactant components is associated with respiratory distress syndrome (RDS) in premature infants and adults with respiratory distress syndrome (ARDS).
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:50Immunohistochemistry (frozen and paraffin): 1:50Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.