84-1107-40　Zic1 (Zinc Finger Protein of the Cerebellum 1, Zic Family Member 1 (Odd-paired Drosophila Homolog), Zic Family Member 1, Zic 1, Zic-1, ZIC, Odd Paired Homolog Drosophila, Zinc Finger Protein ZIC 1, Zinc Finger Protein ZIC1, ZNF201) 100ul　Z0421-81

特徴

• The Zic-1 gene, which encodes a zinc finger protein, is expressed in the developing or matured central nervous system in a highly restricted manner.
• The Zic gene is expressed in granule cells that make synaptic contact with Purkinje cells.
• Clearly Zic-1 is a gene critical to cerebellar pattern formation.
• The expression of Zic genes is first detected at gastrulation and at neurulation, becomes restricted to the dorsal neural ectoderm and the dorsal paraxial mesoderm.
• Zic-2 and Zic-3 are highly similar genes, especially in their product's zinc finger motif and by comparison of their genomic organization in that they share common exon-intron boundaries and belong to the same gene family.
• By comparison in function, Zic-2 is essential for the formation of the brain and Zic-3 is important for right and left axis formation.
• The Zic-1 gene has been mapped to chromosome 9 in mouse.
• The 5' flanking region of the Zic-1 gene contains a region-specific enhancer determined to be essential in in vivo and in vitro deletion analysis.
• The temporal profile of mRNA expression differs for each of the Zic gene products.
• The Drosophila odd-paired gene is highly homologous to the Zic gene family.
• Applications:Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Positive Control: Mouse cerebellum
• Cellular Localization: Nuclear
• Storage and Stability:May be stored at 4°C for short-term only.
• For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C.
• Aliquots are stable for at least 3 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.