This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box.
The protein contains two domains commonly found in transcription factors that confer DNA binding and dimerization capability.
This gene product was also separately identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter.
It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator.
There is also a recent finding that the same agents that cause an ER stress response, the unfolded protein response, also increase transcription of this gene.
This increase in transcription requires an ER stress response consensus binding element in the promoter.
Applications:Suitable for use in Western Blot and Immunocytochemistry.
Other applications not tested.
Recommended Dilutions:Western Blot: 1-2ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
Specificity：Recognizes human XBP-1. Recognizes the spliced and the non-spliced isoforms of XBP-1. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：IC WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to 18 aa near the amino terminus of human XBP-1 (Genbank accession No. BAB82982).
