84-1106-99　TRPA1 (Transient Receptor Potential Cation Channel Subfamily A Member 1, Ankyrin-like with Transmembrane Domains Protein 1, ANKTM1, Transformation Sensitive Protein p120) 100ul　T8666-12C

特徴

• Transient receptor potential ion channels (TRPCs) are a superfamily of six transmembrane segment-spanning, gated cation channels.
• TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction.
• It is a transformation-associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons.
• Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage.
• It is now known that TRPA1 protein is also widely expressed outside of the CNS and is dys-regulated during oncogenic transformation.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 2ug/mlImmunohistochemistry (Paraffin): 1:100-1:250Immunohistochemistry (Frozen): 0.5-1.0ug/mlOptimal dilutions to be determined by the researcher.
• Positive Control:Human brain membrane fraction
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.